85-6830-71 Anti-Mouse MHC Class II In Vivo Antibody - Low Endotoxin （M5/114.15.2） [ICH1176] 5mg ICH1176
![Anti-Mouse MHC Class II In Vivo Antibody - Low Endotoxin （M5/114.15.2） [ICH1176] 5mg](https://aimg.as-1.co.jp/c/85/6830/71/85682291.jpg)
特徴
- 背景：MHC class II antibody, clone M5/114.15.2, recognizes the major histocompatibility complex (MHC) class II molecules I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. MHC class II is constitutively expressed on professional antigen-presenting cells (APCs), including macrophages/monocytes, dendritic cells (DCs), and B cells, and is induced on T cells upon activation. MHC class II consists of two transmembrane proteins, a 35 kDa α (heavy) chain and 29 kDa β (light) chain. The N-terminal α1 and β1 domains form the antigen-binding groove, which binds 13-25 aa peptides derived from exogenous antigens. On APCs, MHC class II plays a critical role in the adaptive immune response by presenting phagocytosed antigens to helper CD4 T cells. The T cell receptor (TCR)/CD3 complex of CD4 T cells interacts with peptide-MHC class II, which induces CD4 T cell activation leading to the coordination and regulation of other effector cells. CD4 molecules also bind to MHC class II, which helps augment TCR signaling. It has also been demonstrated that MHC class II express on activated T cells are capable of antigen presentation and can transduce signals into T cells, enhancing T cell proliferation and activity.
仕様
- サイズ：5mg
- ターゲット：MHC Class II
- クローン：M5/114.15.2
- 免疫動物：Rat
- 交差性：Mouse
- 精製方法：This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
- 抗原：C57BL/6 Spleen Cells
- 濃度：≥ 5.0 mg/ml
- 構成：This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
- 純度：≥95% monomer by analytical SEC, >95% by SDS Page
- エンドトキシン：<1.0 EU/mg as determined by the LAL method
- Aggregation：Aggregation level ≤ 5%
- 適用：Blocking, CODEX®, Flow Cytometry, IHC (Frozen), Immunoprecipitation
- データシート：https://ichor.bio/product/anti-mouse-mhc-class-ii-in-vivo-antibody-low-endotoxin-m5-114-15-2/?action=genpdf&id=80024
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