背景：Coronavirus encodes the 2'-O-MTase（2'O Methyltransferase） that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2'O-methyltransferase (2'O-MTase) is highly conserved. The conserved 2'O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design in an expanding Coronavirus outbreak setting, such as COVID-19. Targeting on the 2'O-methylation pathway on SARS-CoV replication and pathogenesis can be the treatment options for vaccine and anti-viral durgs development which can against SARS-CoV-2，SARS-CoV, MERS-CoV or other RNA and DNA viruses.
仕様
サイズ：100µg
種由来：virus
発現宿主：E. coli
純度：> 85 % as determined by reducing SDS-PAGE.
遺伝子構造：A DNA sequence encoding the SARS-CoV-2 (2019-nCoV) Methyltransferase / ME (YP_009724389.1) (Ser6799-Asn7096) was expressed with a polyhistidine tag at the C-terminus.
別名（遺伝子名）：Methyltransferase, ME
アミノ酸配列：Ser6799-Asn7096
タグ種類：C-6His
アクセッションＮｏ．：YP_009724390.1
エンドトキシン濃度：< 1.0 EU per µg as determined by the LAL method.
分子量：33.46kDa.
組成：Lyophilized from sterile 20 mM Tris 150 mM NaCl, pH 8.3.
保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
