特徴
- 背景:Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
仕様
- サイズ:50µg
- 種由来:Human
- 発現宿主:Human Cells
- 純度:> 95 % as determined by reducing SDS-PAGE.
- 遺伝子構造:Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a Fc tag at the C-terminus.
- 別名(遺伝子名):Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
- アミノ酸配列:Gln18-Ser740
- タグ種類:C-Fc
- アクセッションNo.:Q9BYF1
- エンドトキシン濃度:< 1.0 EU per µg as determined by the LAL method.
- 分子量:110.5 kDa
- 組成:Supplied as a 0.2 μM filtered solution of 20 mM Tris-HCl, 300 mM NaCl, 1 mM ZnCl2, 10% Glycerol, pH 7.4.
- 保存条件:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク:https://www.elabscience.com//viewpdf-375769-Elabscience-PKSR030492.pdf
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商品のバリエーション (サイズ違い・スペック違い・オプション品など)
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-8146-68
Recombinant Human ACE2 Protein (Fc Tag) 10ug
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89-8146-69
Recombinant Human ACE2 Protein (Fc Tag) 50ug
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