背景：Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.
仕様
サイズ：1mg
種由来：Virus
発現宿主：E.coli
純度：> 85 % as determined by reducing SDS-PAGE.
遺伝子構造：Recombinant 2019-nCoV Envelope Protein is produced by our E.coli expression system and the target gene encoding Met1-Val75 is expressed with a BBP, 6His tag at the N-terminus.
別名（遺伝子名）：2019-nCoV E protein; 2019-nCoV sM protein
アミノ酸配列：Met1-Val75
タグ種類：N-6His
アクセッションＮｏ．：QHD43418.1
エンドトキシン濃度：< 1.0 EU per µg as determined by the LAL method.
分子量：27.5 kDa
組成：Supplied as a 0.2 μM filtered solution of 20 mM Tris-HCl, 200 mM NaCl, pH 8.0.
保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
