89-8133-28　Cyclin E1 Polyclonal Antibody 60uL　E-AB-70166

特徴

• 主な研究分野例：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
• 背景：The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.

仕様

• サイズ：60uL
• 抗体タイプ：Polyclonal Antibody
• アプリケーション：IHC
• 交差性：Human
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：0.98 mg/mL
• 抗原：KLH conjugated Synthetic peptide corresponding to Mouse Cyclin E1
• 緩衝液：PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
• 精製方法：Affinity purification
• 希釈倍率：IHC 1:300-1:1000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-51748-Elabscience-E-AB-70166.pdf
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