89-8025-91　［取扱停止］PSEN2 Polyclonal Antibody 60uL　E-AB-62184

特徴

• 主な研究分野例：Cancer, Metabolism, Neuroscience
• 背景：Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

仕様

• サイズ：60uL
• 抗体タイプ：Polyclonal Antibody
• アプリケーション：WB,IHC
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：A synthetic peptide of human PSEN2
• 緩衝液：PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
• 精製方法：Affinity purification
• 希釈倍率：WB1:500 - 1:2000 IHC1:50 - 1:200
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-49696-Elabscience-E-AB-62184.pdf
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