89-7941-16　EWSR1 Polyclonal Antibody 20uL　E-AB-52908

特徴

• 主な研究分野例：Cancer, Epigenetics and Nuclear Signaling, Tags and Cell Markers
• 背景：This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

仕様

• サイズ：20uL
• 抗体タイプ：Polyclonal Antibody
• アプリケーション：WB,IHC,ELISA
• 交差性：Human, Mouse
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1.08 mg/mL
• 抗原：Fusion protein of human EWSR1
• 緩衝液：PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
• 精製方法：Antigen affinity purification
• 希釈倍率：WB 1:1000-1:5000, IHC 1:50-1:300, ELISA 1:5000-1:10000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-271303-Elabscience-E-AB-52908.pdf
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