89-7914-09 HTT Polyclonal Antibody 20uL  E-AB-52008

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特徴

  • 背景:Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

仕様

  • サイズ:20uL
  • 抗体タイプ:Polyclonal Antibody
  • アプリケーション:IHC,ELISA
  • 交差性:Human, Rat
  • 宿主:Rabbit
  • アイソタイプ:IgG
  • 濃度:0.84 mg/mL
  • 抗原:Synthetic peptide of human HTT
  • 緩衝液:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
  • 精製方法:Antigen affinity purification
  • 希釈倍率:IHC 1:40-1:200, ELISA 1:5000-1:10000
  • 標識:Unconjugated
  • クローナリティ:Polyclonal
  • メーカーマニュアルリンク:https://www.elabscience.com/viewpdf-256013-Elabscience-E-AB-52008.pdf
  • この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)

アズワン品番 89-7914-09
型番 E-AB-52008
標準価格 32,000円(税抜)
WEB価格
入り数 1個
アズワン在庫 [?]
サプライヤ在庫 [?]
出荷予定日
数量

商品のバリエーション (サイズ違い・スペック違い・オプション品など)

アズワン品番 商品名 型番 入り数 標準価格
(税抜)
WEB価格
(税抜)
アズワン在庫[?]
[サプライヤ在庫]
89-7914-09 HTT Polyclonal Antibody 20uL  E-AB-52008
E-AB-52008
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1個 32,000円

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1個 39,000円

89-7914-11 HTT Polyclonal Antibody 120uL  E-AB-52008
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89-7914-12 HTT Polyclonal Antibody 200uL  E-AB-52008
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