89-7913-76　Phospho-SMAD3 (Ser425) Monoclonal Antibody 20uL　E-AB-51043

特徴

• 主な研究分野例：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction, Stem Cells
• 背景：Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

仕様

• サイズ：20uL
• 抗体タイプ：Phosphorylated antibody
• アプリケーション：IHC-p
• 交差性：Human,Mouse,Rat
• 宿主：Mouse
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：Synthetic Peptide of Phospho-Smad3 (Ser425)
• 緩衝液：PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
• 精製方法：Protein A purification
• 希釈倍率：IHC 1:50-300
• 標識：Unconjugated
• クローナリティ：Monoclonal
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

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