89-7913-65　Phospho-AKT1 (Ser473) Monoclonal Antibody 60uL　E-AB-51038

特徴

• 主な研究分野例：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
• 背景：The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

仕様

• サイズ：60uL
• 抗体タイプ：Phosphorylated antibody
• アプリケーション：WB,IHC-p
• 交差性：Human
• 宿主：Mouse
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：Synthetic Peptide of Phospho-Akt (S473)
• 緩衝液：PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
• 精製方法：Protein A purification
• 希釈倍率：WB 1:1000-2000, IHC 1:100-200
• 標識：Unconjugated
• クローナリティ：Monoclonal
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

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