89-7908-75　［取扱停止］GCK Polyclonal Antibody 20uL　E-AB-40270

特徴

• 主な研究分野例：Cancer, Metabolism, Signal Transduction
• 背景：Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

仕様

• サイズ：20uL
• 抗体タイプ：Polyclonal Antibody
• アプリケーション：WB,IHC,IF
• 交差性：Human,Mouse
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：Recombinant Mouse Glucokinase protein
• 緩衝液：PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
• 精製方法：Antigen Affinity Purification
• 希釈倍率：WB 1:1000-1:2000 IHC 1:100-1:200 IF 1:100-1:400
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-104552-Elabscience-E-AB-40270.pdf
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