89-7908-52　［取扱停止］p16 Polyclonal Antibody 60uL　E-AB-40264

特徴

• 主な研究分野例：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
• 背景：This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.

仕様

• サイズ：60uL
• 抗体タイプ：Polyclonal Antibody
• アプリケーション：IHC,IF
• 交差性：Human,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：0.82 mg/mL
• 抗原：Recombinant Rat Cyclin-dependent kinase inhibitor 2A protein
• 緩衝液：PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
• 精製方法：Antigen Affinity Purification
• 希釈倍率：IHC 1:50-1:200 IF 1:100-1:200
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-104546-Elabscience-E-AB-40264.pdf
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