89-7893-63　CEND1 Polyclonal Antibody 200uL　E-AB-19691

特徴

• 主な研究分野例：Cancer, Cell Biology, Neuroscience, Tags & Cell Markers
• 背景：BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

仕様

• サイズ：200uL
• 抗体タイプ：Polyclonal Antibody
• アプリケーション：WB,IHC,ELISA
• 交差性：Human, Mouse, Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：0.9 mg/mL
• 抗原：Synthetic peptide of human CEND1
• 緩衝液：PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
• 精製方法：Antigen affinity purification
• 希釈倍率：WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-255696-Elabscience-E-AB-19691.pdf
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