89-7857-83　PHF21A Polyclonal Antibody 200uL　E-AB-18538

特徴

• 主な研究分野例：Epigenetics and Nuclear Signaling, Neuroscience
• 背景：Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.

仕様

• サイズ：200uL
• 抗体タイプ：Polyclonal Antibody
• アプリケーション：WB,IHC,ELISA
• 交差性：Human, Mouse
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：0.6 mg/mL
• 抗原：Fusion protein of human PHF21A
• 緩衝液：PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
• 精製方法：Antigen affinity purification
• 希釈倍率：WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-254543-Elabscience-E-AB-18538.pdf
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