89-7834-76 Recombinant Rat PD-L1/B7-H1/CD274 Protein (C-His) 50ug PKSR030458
[Elabscience]
特徴
- 背景：CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
仕様
- サイズ：50ug
- 種由来：Rat
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：D4AE25
- タグ種類：C-His
- アミノ酸配列：Ala18-Thr238
- 遺伝子構造：Recombinant Rat PD-L1 is produced by our Mammalian expression system and the target gene encoding Ala18-Thr238 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：B7-H;B7-H1;B7H1;PD-L1;PDCD1L1;PDCD1LG1;PDL1
- 分子量：26.1 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229841-Elabscience-PKSR030458.pdf
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89-7834-75
Recombinant Rat PD-L1/B7-H1/CD274 Protein (C-His) 10ug
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89-7834-76
Recombinant Rat PD-L1/B7-H1/CD274 Protein (C-His) 50ug
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