89-7834-28 Recombinant Rat ALK-1/ACVRL1 Protein (His & Fc Tag)(Active) 200ug PKSR030416
[Elabscience]
特徴
- 背景：Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
仕様
- サイズ：200ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method
- アクセッションＮｏ．：NP_071886.1
- タグ種類：C-His-Fc
- アミノ酸配列：Met 1-Ala 118
- 遺伝子構造：A synthetic DNA sequence encoding the rat ACVRL1 (NP_071886.1) extracellular domain (Met 1-Ala 118) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953.The ED50 for this effect is typically 40-200 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
- 別名（遺伝子名）：R3;R-3;SETHKIR;MGC91691;Acvrl1
- 分子量：38.7 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38483-Elabscience-PKSR030416.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7834-27
Recombinant Rat ALK-1/ACVRL1 Protein (His & Fc Tag)(Active) 100ug
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89-7834-28
Recombinant Rat ALK-1/ACVRL1 Protein (His & Fc Tag)(Active) 200ug
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