89-7833-57 Recombinant Rat Tie2/TEK Protein (Fc Tag)(Active) 200ug PKSR030377
[Elabscience]
特徴
- 背景：TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
仕様
- サイズ：200ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method
- アクセッションＮｏ．：NP_001099207.1
- タグ種類：C-Fc
- アミノ酸配列：Met 4-Leu 743
- 遺伝子構造：A DNA sequence encoding the rat TEK (NP_001099207.1) extracellular domain (Met 4-Leu 743) was fused with the Fc region of human IgG1 at the C-terminus.
- 活性：1. Measured by its binding ability in a functional ELISA.2. Immobilized S1h-3C-mANGPT2 at 10 μg/mL (100 μL/well) can bind ratTEK-Fc.The EC50 of ratTEK-Fc is 0.26-0.62μg/mL.
- 別名（遺伝子名）：Tie-2;Tie2
- 分子量：108 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38455-Elabscience-PKSR030377.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7833-56
Recombinant Rat Tie2/TEK Protein (Fc Tag)(Active) 100ug
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89-7833-57
Recombinant Rat Tie2/TEK Protein (Fc Tag)(Active) 200ug
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