89-7833-27 Recombinant Rat EphA7/EHK3 Protein (Fc Tag)(Active) 200ug PKSR030361
[Elabscience]
特徴
- 背景：Ephrin type-A receptor 7, also known as EphA7, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. The expression of EphA7 was reduced in all tested gastric cancer cell lines; however, there is marked variability in expression among gastric carcinoma specimens. EphA7 may have roles in the pathogenesis and development of gastric carcinomas.
仕様
- サイズ：200ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg protein as determined by the LAL method.
- アクセッションＮｏ．：NP_599158.1
- タグ種類：C-Fc
- アミノ酸配列：Met1-Ser539
- 遺伝子構造：A DNA sequence encoding the rat Epha7 (NP_599158.1) (Met1-Ser539) was expressed with the Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA.Immobilized mouse EFNA4-His at 10 μg/ml (100 μl/well) can bind rat EPHA7-Fc3, The EC50 of rat EPHA7-Fc3 is 10-30 ng/mL.
- 別名（遺伝子名）：EPHA7;Ehk-3;Ehk3
- 分子量：58.9 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38445-Elabscience-PKSR030361.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7833-27
Recombinant Rat EphA7/EHK3 Protein (Fc Tag)(Active) 200ug
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89-7833-26
Recombinant Rat EphA7/EHK3 Protein (Fc Tag)(Active) 50ug
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