89-7832-97 ［取扱停止］Recombinant Rat TNFRSF17/BCMA Protein (Fc Tag) 50ug PKSR030347
[Elabscience]
特徴
- 背景：Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.
仕様
- サイズ：50ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 99 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method
- アクセッションＮｏ．：D3ZKQ8
- タグ種類：N-Fc
- アミノ酸配列：Met1-Thr49
- 遺伝子構造：A DNA sequence encoding the rat TNFRSF17 (D3ZKQ8) (Met1-Thr49) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
- 別名（遺伝子名）：TNFRSF17
- 分子量：34 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38437-Elabscience-PKSR030347.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7832-97
Recombinant Rat TNFRSF17/BCMA Protein (Fc Tag) 50ug
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89-7832-98
Recombinant Rat TNFRSF17/BCMA Protein (Fc Tag) 100ug
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