89-7832-71 Recombinant Rat IL17RA Protein (Fc Tag)(Active) 100ug PKSR030332
[Elabscience]
特徴
- 背景：Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
仕様
- サイズ：100ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method
- アクセッションＮｏ．：NP_001101353.2
- タグ種類：C-Fc
- アミノ酸配列：Met1-Pro320
- 遺伝子構造：A DNA sequence encoding the rat IL17RA (NP_001101353.2)(Met1-Pro320) was expressed with the Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA.Immobilized mouse Il17A at 10 μg/ml (100 μl/well) can bind Rat IL17RA, The EC50 of RatIL17RA is 12.0-29.0 ng/ml.
- 別名（遺伝子名）：IL17RA
- 分子量：59.7 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38429-Elabscience-PKSR030332.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7832-71
Recombinant Rat IL17RA Protein (Fc Tag)(Active) 100ug
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89-7832-72
Recombinant Rat IL17RA Protein (Fc Tag)(Active) 200ug
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