89-7832-62 Recombinant Rat Interleukin-25/IL-25 Protein (Fc Tag)(Active) 50ug PKSR030327
[Elabscience]
特徴
- 背景：Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.
仕様
- サイズ：50ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method
- アクセッションＮｏ．：D3ZLB1
- タグ種類：N-Fc
- アミノ酸配列：Val17-Ala169
- 遺伝子構造：A DNA sequence encoding the rat IL25 (D3ZLB1) (Val17-Ala169) was expressed, fused with Fc region of human IgG1 at the N-terminus.
- 活性：Measured by its binding ability in a functional ELISA.Immobilized mouse IL17BR-His at 10 μg/mL (100 μl/well) can bind rat Fc-IL25. The EC50 of rat Fc-IL25 is 0.12-0.27 μg/mL.
- 別名（遺伝子名）：IL25
- 分子量：46.1 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106994-Elabscience-PKSR030327.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7832-62
Recombinant Rat Interleukin-25/IL-25 Protein (Fc Tag)(Active) 50ug
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89-7832-61
Recombinant Rat Interleukin-25/IL-25 Protein (Fc Tag)(Active) 20ug
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