89-7831-76 ［取扱停止］Recombinant Rat CLEC2D/OCIL Protein (Fc Tag) 20ug PKSR030282
[Elabscience]
特徴
- 背景：Lectin-like transcript 1 (LLT1) encoded by CLEC2D gene is a C-type lectin-like molecule interacting with human CD161 (NKR-P1A) receptor expressed by natural killer cells and subsets of T cells. CLEC2D transcripts were detected primarily in hematopoietic cell lines and were found to be co-induced by the same activation signals. Although very low amounts of putative soluble CLEC2D protein isoforms could be produced by transfectants, CLEC2D isoforms 2 and 4 were efficiently expressed. CLEC2D uses gene splicing to generate protein isoforms that are structurally distinct and that have different biological activities. Prostate cancer is the most common type of cancer diagnosed and the second leading cause of cancer-related death in American men. Natural Killer (NK) cells are the first line of defense against cancer and infections. NK cell function is regulated by a delicate balance between signals received through activating and inhibitory receptors. Previously, we identified Lectin-like transcript-1 (LLT1/OCIL/CLEC2D) as a counter-receptor for the NK cell inhibitory receptor NKRP1A (CD161). Interaction of LLT1 expressed on target cells with NKRP1A inhibits NK cell activation.
仕様
- サイズ：20ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：(76.7+14.8) % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method
- アクセッションＮｏ．：NP_569086.1
- タグ種類：N-Fc
- アミノ酸配列：Lys98-Leu233
- 遺伝子構造：A DNA sequence encoding the rat CLEC2D (NP_569086.1) (Lys98-Leu233) was expressed with Fc region of human IgG1 at the N-terminus.
- 別名（遺伝子名）：CLEC2D
- 分子量：44 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38392-Elabscience-PKSR030282.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7831-77
Recombinant Rat CLEC2D/OCIL Protein (Fc Tag) 100ug
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89-7831-76
Recombinant Rat CLEC2D/OCIL Protein (Fc Tag) 20ug
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