89-7830-10 Recombinant Rat IL23R/IL23 Receptor Protein (Fc Tag)(Active) 50ug PKSR030186
[Elabscience]
特徴
- 背景：IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.
仕様
- サイズ：50ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：(75.1+16.6) as determined by SDS-PAGE
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：XP_003753958.1
- タグ種類：C-Fc
- アミノ酸配列：Met1-Asp367
- 遺伝子構造：A DNA sequence encoding the rat IL23R (Met1-Asp367) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its ability to bind recombinant mouse IL12Bh (m)+mIL23Ah in a functional ELISA.
- 別名（遺伝子名）：IL23R
- 分子量：69.4 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106966-Elabscience-PKSR030186.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7830-09
Recombinant Rat IL23R/IL23 Receptor Protein (Fc Tag)(Active) 20ug
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89-7830-10
Recombinant Rat IL23R/IL23 Receptor Protein (Fc Tag)(Active) 50ug
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