89-7829-89 ［取扱停止］Recombinant Rat Beta-2-microglobulin/B2M Protein (His Tag) 50ug PKSR030175
[Elabscience]
特徴
- 背景：B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.
仕様
- サイズ：50ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method
- アクセッションＮｏ．：P07151
- タグ種類：C-His
- アミノ酸配列：Met 1-Met 119
- 遺伝子構造：A DNA sequence encoding the rat B2M (P07151) (Met 1-Met 119) was expressed, fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：B2M
- 分子量：13 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38322-Elabscience-PKSR030175.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7829-88
Recombinant Rat Beta-2-microglobulin/B2M Protein (His Tag) 20ug
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89-7829-89
Recombinant Rat Beta-2-microglobulin/B2M Protein (His Tag) 50ug
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