89-7829-60 ［取扱停止］Recombinant Rat Interleukin-17F/IL-17F Protein (His Tag)(Active) 20ug PKSR030160
[Elabscience]
特徴
- 背景：Interleukin-17F (IL-17F) is a cytokine that shares sequence similarity with IL17. The most notable role of IL-17 is it involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with allergic responses. IL-17F is expressed by activated T cells, and was expressed only in activated CD4+ T cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines, including IL6 and IL8. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-{beta}, and monocyte chemoattractant protein-1. IL-17F stimulates the production of other cytokines and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL-17F stimulates PBMC and T-cell proliferation. It also function in inhibiting angiogenesis By similarity. IL-17F plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.
仕様
- サイズ：20ug
- 種由来：Rat
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg protein as determined by the LAL method.
- アクセッションＮｏ．：NP_001015011.1
- タグ種類：C-His
- アミノ酸配列：Met1-Ala153
- 遺伝子構造：A DNA sequence encoding the rat Il17f (NP_001015011.1) (Met1-Ala153) was expressed with a polyhistidine tag at the C-terminus.
- 活性：1. Measured by its binding ability in a functional ELISA.2. Immobilized rat IL17F-His at 10 μg/mL (100 μL/well) can bind Rat IL17RA-Fc3 . The EC50 of Rat IL17RA-Fc3 is 0.28-0.66 μg/mL.
- 別名（遺伝子名）：IL17F;IL-17F
- 分子量：16.4 kDa
- 組成：Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38314-Elabscience-PKSR030160.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7829-60
Recombinant Rat Interleukin-17F/IL-17F Protein (His Tag)(Active) 20ug
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89-7829-61
Recombinant Rat Interleukin-17F/IL-17F Protein (His Tag)(Active) 50ug
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