89-7829-33 Recombinant Rat CLPS/Colipase Protein (His Tag) 100ug PKSR030146
[Elabscience]
特徴
- 背景：Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural analogies have been recognised between a developmental protein, the pancreatic lipase C-terminal domain, the N-terminal domains of lipoxygenases and the C-terminal domain of alpha-toxin. Colipase can only be detected in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Colipase allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Colipase is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising as active conformation and considerably increasing the overall hydrophobic binding site.
仕様
- サイズ：100ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg protein as determined by the LAL method.
- アクセッションＮｏ．：NP_037271.1
- タグ種類：C-His
- アミノ酸配列：Met1-Gln112
- 遺伝子構造：A DNA sequence encoding the rat Clps (NP_037271.1) (Met1-Gln112) was expressed with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：CLPS;Colipase
- 分子量：11.9 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106951-Elabscience-PKSR030146.pdf
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89-7829-33
Recombinant Rat CLPS/Colipase Protein (His Tag) 100ug
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89-7829-32
Recombinant Rat CLPS/Colipase Protein (His Tag) 20ug
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