89-7829-27 Recombinant Rat IL6RA/CD126 Protein (Fc tag, ECD) 100ug PKSR030143
[Elabscience]
特徴
- 背景：Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：100ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg protein as determined by the LAL method.
- アクセッションＮｏ．：NP_058716.2
- タグ種類：C-Fc
- アミノ酸配列：Met1-Pro364
- 遺伝子構造：A DNA sequence encoding the rat Il6r (NP_058716.2) (Met1-Pro364) was expressed with the Fc region of human IgG1 at the C-terminus.
- 別名（遺伝子名）：Il6ra;IL-6R
- 分子量：64.8 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38303-Elabscience-PKSR030143.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7829-27
Recombinant Rat IL6RA/CD126 Protein (Fc tag, ECD) 100ug
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89-7829-26
Recombinant Rat IL6RA/CD126 Protein (Fc tag, ECD) 20ug
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