89-7829-13 ［取扱停止］Recombinant Rat B7-H6/NCR3LG1 Protein (ECD, Fc Tag)(Active) 200ug PKSR030136
[Elabscience]
特徴
- 背景：Natural cytotoxicity triggering receptor 3 ligand 1(B7-H6) is a glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H6 consists of a 238 amino acid (aa) extracellular domain (ECD) that contains one Ig-like V domain and one Ig-like C1 domain, a 21 aa transmembrane segment, and a 171 aa cytoplasmic domain that contains one ITIM, one SH2, and one SH3 motif. Both of the Ig-like domains carry N-linked glycosylation. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors.
仕様
- サイズ：200ug
- 種由来：Rat
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg protein as determined by the LAL method.
- アクセッションＮｏ．：XP_006223356.1
- タグ種類：C-Fc
- アミノ酸配列：Met1-Ser308
- 遺伝子構造：A DNA sequence encoding the rat NCR3LG1 (XP_006223356.1) (Met1-Ser308) was expressed with the Fc region of human IgG1 at the C-terminus.
- 活性：1.Measured by its binding ability in a functional ELISA. 2.Immobilized rat NCR3-His at 10μg/mL (100μL/well) can bind rat B7-H6-Fc , the EC50 of rat B7-H6 -Fc is 1-20ng/mL.
- 別名（遺伝子名）：B7H6
- 分子量：60.4 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-106948-Elabscience-PKSR030136.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7829-12
Recombinant Rat B7-H6/NCR3LG1 Protein (ECD, Fc Tag)(Active) 50ug
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89-7829-13
Recombinant Rat B7-H6/NCR3LG1 Protein (ECD, Fc Tag)(Active) 200ug
|
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