89-7828-46 Recombinant Rhesus macaque HVEM/TNFRSF14/CD270 Protein (His Tag) 50ug PKSQ050069
[Elabscience]
特徴
- 背景：Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.
仕様
- サイズ：50ug
- 種由来：Rhesus macaque
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：F7GSW4
- タグ種類：C-His
- アミノ酸配列：Leu39-Val203
- 遺伝子構造：Recombinant Rhesus macaque HVEM is produced by our Mammalian expression system and the target gene encoding Leu39-Val203 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM
- 分子量：18.3 kDa
- 組成：Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229815-Elabscience-PKSQ050069.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7828-46
Recombinant Rhesus macaque HVEM/TNFRSF14/CD270 Protein (His Tag) 50ug
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89-7828-45
Recombinant Rhesus macaque HVEM/TNFRSF14/CD270 Protein (His Tag) 10ug
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