89-7827-52 Recombinant Cynomolgus TIM-3/HAVCR2 Protein (His Tag) 10ug PKSQ050023
[Elabscience]
特徴
- 背景：T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
仕様
- サイズ：10ug
- 種由来：Cynomolgus
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：G7P6Q7
- タグ種類：N-His
- アミノ酸配列：Ser22-Arg201
- 遺伝子構造：Recombinant Cynomolgus TIM-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg201 is expressed with a 8His tag at the N-terminus.
- 別名（遺伝子名）：T cell immunoglobulin and mucin domain3; HAVCR2; Tim-3; TIM3
- 分子量：20.8 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229769-Elabscience-PKSQ050023.pdf
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89-7827-53
Recombinant Cynomolgus TIM-3/HAVCR2 Protein (His Tag) 50ug
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89-7827-52
Recombinant Cynomolgus TIM-3/HAVCR2 Protein (His Tag) 10ug
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