89-7827-29 Recombinant Cynomolgus LAG-3/CD223 Protein (His Tag) 50ug PKSQ050011
[Elabscience]
特徴
- 背景：Lymphocyte Activating 3(LAG3) belongs to immunoglobulin (Ig) superfamily, Macaca fascicularis LAG3 cDNA encodes 533 amino acids (aa) that include a 17 aa signal sequence, a 451 aa extracellular domain (ECD) with two Ig-like domains, a transmembrane region and a highly charged cytoplasmic region. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.
仕様
- サイズ：50ug
- 種由来：Cynomolgus
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：XP_005570011.1
- タグ種類：N-His
- アミノ酸配列：Pro23-Leu450(Pro74)
- 遺伝子構造：Recombinant Cynomolgus LAG-3 is produced by our Mammalian expression system and the target gene encoding Pro23-Leu450(Pro74) is expressed with a 8His tag at the N-terminus.
- 活性：Immobilized Cynomolgus LAG-3-His at 2μg/ml(100 μl/well) can bind Human FGL1-Fc. The ED50 of Cynomolgus LAG-3-His is 5.8 ug/ml .
- 別名（遺伝子名）：Lymphocyte Activating 3; LAG3; LAG-3; CD223
- 分子量：47.3 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS,PH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229757-Elabscience-PKSQ050011.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7827-29
Recombinant Cynomolgus LAG-3/CD223 Protein (His Tag) 50ug
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89-7827-28
Recombinant Cynomolgus LAG-3/CD223 Protein (His Tag) 10ug
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