特徴
- 背景：LRIG1 is a leucine-rich repeat (LRR) and Ig-like domain-containing single-pass transmembrane glycoprotein. LRIG1 shares 45-50% aa identity with its mammalian paralogs, LRIG2 and LRIG3. LIRG1 is expressed widely throughout mouse and human tissues, including the liver, brain, stomach, small intestine, skeletal muscle, cornea, and hair follicle. It has been shown to suppress tumor growth, regulate tissue homeostasis, and maintain stem cell quiescence. The LRIG1 ECD contains three C-type Ig-like domains as well as fifteen LRRs that are flanked by cysteine-rich regions. LRIG1 functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. LRIG1 expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse? Decreased LRIG1 is associated with an increase in recurrence and mortality for a variety of cancers including breast, uterine, headandneck, glioma, prostate, and squamous cell. Tissue homeostasis and stem cell dormancy is also thought to be modulated by the actions of LRIG1 on cell proliferation.
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P70193
- タグ種類：C-His
- アミノ酸配列：Ala35-Thr794
- 遺伝子構造：Recombinant Mouse LRIG1 is produced by our Mammalian expression system and the target gene encoding Ala35-Thr794 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1; Lrig1
- 分子量：84.5 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229692-Elabscience-PKSM041310.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7825-92
Recombinant Mouse LRIG1 Protein (His Tag) 10ug
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89-7825-93
Recombinant Mouse LRIG1 Protein (His Tag) 50ug
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