89-7825-80 Recombinant Mouse Mesothelin/MSLN Protein (His Tag) 10ug PKSM041304
[Elabscience]
特徴
- 背景：Mesothelin is derived from a 70 kDa precursor that also includes Megakaryocyte Potentiating Factor (MPF).The 70 kDa precursor is expressed on the cell surface where it is cleaved at a dibasic proteolytic site to release the 32 kDa glycosylated MPF. MPF is a cytokine that potentiates IL3 induced megakaryocyte colony formation. The term Mesothelin refers to the 40 kDa glycosylated protein which remains attached to the cell surface via a GPI linkage. Mesothelin is over expressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The interaction between mesothelin and MUC16 (also known as CA125) may facilitate the implantation and peritoneal spread of tumors by cell adhesion. The region (296-359) consisting of 64 amino acids at the N-terminal of cell surface mesothelin is the functional binding domain for MUC16. Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. A soluble form of Mesothelin, with its GPI anchor intact, is released from tumor cells and binds to MMR/CD206 on macrophages.
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q61468
- タグ種類：C-His
- アミノ酸配列：Asp298-Ser600
- 遺伝子構造：Recombinant Mouse Mesothelin is produced by our Mammalian expression system and the target gene encoding Asp298-Ser600 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Mesothelin; Msln; Mes; Mpf; CAK1; MSLN
- 分子量：35 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229686-Elabscience-PKSM041304.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7825-81
Recombinant Mouse Mesothelin/MSLN Protein (His Tag) 50ug
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89-7825-80
Recombinant Mouse Mesothelin/MSLN Protein (His Tag) 10ug
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