89-7825-63 Recombinant Mouse CD31/PECAM1 Protein (His Tag) 50ug PKSM041295
[Elabscience]
特徴
- 背景：Platelet endothelial cell adhesion molecule (PECAM-1, CD31) is a type I transmembrane glycoprotein adhesion molecule in the immunoglobulin superfamily. PECAM-1 is concentrated at cell junctions and is required for transendothelial migration (TEM). The extracellular domain (ECD) of PECAM-1 has ten potential N-linked glycosylation sites and six C2-type Ig-like domains, the first of which is critical for adhesion and extravasation. The cytoplasmic domain contains immunoregulatory tyrosine-based inhibitory and switch motifs (ITIM, ITSM) that mediate both inhibition and activation via phosphotyrosine-mediated engagement of SH2-containing signaling molecules. Expression is restricted to cells involved in circulation, especially endothelial cells, platelets, monocytes, neutrophils and lymphocyte subsets. PECAM-1 participates with other adhesion molecules in some functions, but is the critical molecule for TEM. Homotypic PECAM-1 adhesion in trans, combined with cycling of PECAM-1 to and from surface-connected endothelial cell vesicles, leads leukocytes across endothelial tight junctions.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q08481
- タグ種類：C-His
- アミノ酸配列：Glu18-Lys590
- 遺伝子構造：Recombinant Mouse PECAM-1 is produced by our Mammalian expression system and the target gene encoding Glu18-Lys590 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Platelet endothelial cell adhesion molecule; PECAM-1; CD31; Pecam1; Pecam
- 分子量：63.4 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229677-Elabscience-PKSM041295.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7825-63
Recombinant Mouse CD31/PECAM1 Protein (His Tag) 50ug
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89-7825-62
Recombinant Mouse CD31/PECAM1 Protein (His Tag) 10ug
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