89-7824-89 Recombinant Mouse PD-L1/B7-H1/CD274 Protein (Fc Tag) 10ug PKSM041256
[Elabscience]
特徴
- 背景：Mouse Programmed cell death 1 ligand 1(Cd274,PD-L1), is a member of the growing B7 family of immune proteins.It involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.B7-H1 has been identified as one of two ligands for programmed death1 (PD1), a member of the CD28 family of immunoreceptors. B7-H1 is constitutively expressed in several organs such as heart, skeletal muscle B7-H1 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. The costimulatory function of B7-H1 is critical for enhancing maturation and differentiation of T-cells in lymphoid organs.B7-H1 expression is also induced in dendritic cells and keratinocytes after IFN gamma stimulation. Interaction of B7-H1 with PD1 results in inhibition of TCR-mediated proliferation and cytokine production. The B7-H1:PD1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：> 95% as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q9EP73
- タグ種類：C-Fc
- アミノ酸配列：Phe19-Thr238
- 遺伝子構造：Recombinant Mouse PD-L1 is produced by our Mammalian expression system and the target gene encoding Phe19-Thr238 is expressed with a Fc tag at the C-terminus.
- 別名（遺伝子名）：Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1;PD-L1;PDCD1 ligand 1;programmed death ligand 1;B7 homolog 1;B7-H1;CD274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1
- 分子量：51.7 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-229641-Elabscience-PKSM041256.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7824-89
Recombinant Mouse PD-L1/B7-H1/CD274 Protein (Fc Tag) 10ug
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89-7824-90
Recombinant Mouse PD-L1/B7-H1/CD274 Protein (Fc Tag) 50ug
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