特徴
- 背景：CD5L, also known as CD5 antigen-like, is secreted protein which mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. It is able to inhibit lipid droplet size in adipocytes. CD5L acts as a key regulator of metabolic switch in T-helper Th17 cells. It is Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies. It also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis. It is involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy.
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q9QWK4
- タグ種類：C-6His
- アミノ酸配列：Glu22-VaL352
- 遺伝子構造：Recombinant Mouse CD5 antigen-like is produced by our Mammalian expression system and the target gene encoding Glu22-VaL352 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：CD5 antigen-like;Apoptosis inhibitor expressed by macrophages;Apoptosis inhibitory 6;CT-2;SP-alpha;Cd5l;Aim; Api6;AAC-11; AI047839; Api6; CT2; Pdp; Sp-alpha
- 分子量：37.4 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-139548-Elabscience-PKSM041246.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7824-73
Recombinant Mouse CD5L Protein (His Tag) 10ug
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89-7824-74
Recombinant Mouse CD5L Protein (His Tag) 50ug
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