89-7823-63 Recombinant Mouse Legumain/LGMN Protein (His Tag) 50ug PKSM041191
[Elabscience]
特徴
- 背景：Mouse Legumain,also known as LGMN, is a cysteine protease belonging to peptidase family C13 and is expressed in kidney and placenta abundantly. LGMN has a strict specificity for hydrolysis of asparaginyl bonds. It can also cleave aspartyl bonds slowly, especially under acidic conditions. The mammalian legumain is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. It plays a role in the regulation of cell proliferation via its role in EGFR degradation. Legumain deficiency causes the accumulation of pro-Cathepsins B, H and L, another group of lysosomal cysteine proteases. Overexpression of Legumain in tumors is significant for invasion/metastasis. Mammalian legumain is inhibited by iodoacetamide and maleimides. Legumain activation appears to be autocatalytic and can be triggered by acidic pH.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：NP_035305.1
- タグ種類：C-6His
- アミノ酸配列：Val 18-Tyr 435
- 遺伝子構造：Recombinant Mouse Legumain/Asparaginyl Endopeptidase is produced by our Mammalian expression system and the target gene encoding Val18-Tyr435 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Legumain;Lgmn;Asparaginyl endopeptidase;Protease cysteine 1;Prsc1;AEP
- 分子量：48.7 kDa
- 組成：Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,20% Glycerol,pH8.0.
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-139494-Elabscience-PKSM041191.pdf
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89-7823-62
Recombinant Mouse Legumain/LGMN Protein (His Tag) 10ug
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89-7823-63
Recombinant Mouse Legumain/LGMN Protein (His Tag) 50ug
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