89-7822-43 Recombinant Mouse RANK/TNFRSF11A Protein (His Tag) 10ug PKSM041130
[Elabscience]
特徴
- 背景：Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, brain and kidney, but weakly expressed in spleen and bone marrow. After binding its ligand RANKL, RANK can activate signaling pathways such as NF-κB, JNK, ERK, p38, and Akt/PKB, through TRAF protein phosphorylation. RANK/TNFRSF11A signaling is largely considered to be growth promoting and apoptosis reducing such as the effects observed in osteoclasts. RANK/TNFRSF11A was also found to be involved in the regulation of interactions between T-cells and dendritic cells.
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：O35305
- タグ種類：C-6His
- アミノ酸配列： Val31-Ser214
- 遺伝子構造：Recombinant Mouse Receptor Activator of NF-kappa B is produced by our Mammalian expression system and the target gene encoding Val31-Ser214 is expressed with a 6His tag at the C-terminus.
- 別名（遺伝子名）：Receptor activator of NF-KB; tumor necrosis factor receptor superfamily member 11A; TRANCE receptor; Osteoclast differentiation factor receptor;NFKB activator; TRANCER; CD265; TNFRSF11A; TRANCE R; CD265 antigen; ODFR
- 分子量：21.3 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107397-Elabscience-PKSM041130.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7822-44
Recombinant Mouse RANK/TNFRSF11A Protein (His Tag) 50ug
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89-7822-43
Recombinant Mouse RANK/TNFRSF11A Protein (His Tag) 10ug
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