特徴
- 背景：Natural cytotoxicity triggering receptor 1(NKp46/NCR1) is a single-pass type I membrane protein. It consists of two extracellular Ig-like domains followed by a short stalk region, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmictail. NKp46 is predominantly expressed in the embryo. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor celllines.
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：Human Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：Q8C567
- タグ種類：C-6His
- アミノ酸配列：Glu22-Asn255
- 遺伝子構造：Recombinant Mouse Natural cytotoxicity triggering receptor 1 is produced by our Mammalian expression system and the target gene encoding Glu22-Asn255 is expressed with a Fc tag at the C-terminus.
- 別名（遺伝子名）：Activating receptor1; mAR-1; Lymphocyte antigen94; Naturalkiller cell p46-related protein; NK-p46; NKp46; mNKp46
- 分子量：53.5 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107381-Elabscience-PKSM041113.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7822-11
Recombinant Mouse NCR1 Protein (His Tag) 10ug
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89-7822-12
Recombinant Mouse NCR1 Protein (His Tag) 50ug
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