89-7819-86 Recombinant Mouse Complement Component C5/C5 Protein 10ug PKSM040990
[Elabscience]
特徴
- 背景：Mouse Complement C5 (C5a) is a glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 77 amino acid peptide that is created by the C5a convertase proteolytic cleavage of C5 αchain in the classical and alternative complement pathway (C4b2a3b, C3bBb3b). Mouse C5a has fourαhelices, plus three intra-chain disulfide bonds that form a triple loop structure. C5a functions via G-protein coupled receptor (GPCR) (C5aR/CD88). C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. It mediates IL-8 release from bronchial epithelial cells. It also triggers an oxidative burst in macrophages and neutrophils, causing release of histamine in basophils and mast cells. C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with nonparenchymal cell via prostanoid secretion. Mouse C5a shares 60% and 82% sequence identity to human and rat C5a, respectively.
仕様
- サイズ：10ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg as determined by the LAL method.
- アクセッションＮｏ．：P06684
- アミノ酸配列：Asn679-Arg755
- 遺伝子構造：Recombinant Mouse Complement Component C5 is produced by our E.coli expression system and the target gene encoding Asn679-Arg755 is expressed.
- 別名（遺伝子名）：Complement C5; Hemolytic Complement; C5; Hc
- 分子量：9.0 kDa
- 組成：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 350mM NaCl, pH 7.5.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-107267-Elabscience-PKSM040990.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7819-86
Recombinant Mouse Complement Component C5/C5 Protein 10ug
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89-7819-87
Recombinant Mouse Complement Component C5/C5 Protein 50ug
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