89-7818-37 ［取扱停止］Recombinant Mouse B7-H4/VTCN1 Protein (aa 29-256, Fc Tag) 50ug PKSM040913
[Elabscience]
特徴
- 背景：V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type? membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：Q7TSP5
- タグ種類：C-Fc
- アミノ酸配列：phe 29-Ser 256
- 遺伝子構造：A DNA sequence encoding the mature form of mouse B7H4 (Q7TSP5) (phe 29-Ser 256) was fused with the Fc region of human IgG1 at the C-terminus.
- 別名（遺伝子名）：V-set domain containing T-cell activation inhibitor 1;B7 homolog 4;Protein B7S1;B7-H4;VTCN1;B7h4;B7s1;B7x;BC032925
- 分子量：52.2 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38916-Elabscience-PKSM040913.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7818-37
Recombinant Mouse B7-H4/VTCN1 Protein (aa 29-256, Fc Tag) 50ug
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89-7818-38
Recombinant Mouse B7-H4/VTCN1 Protein (aa 29-256, Fc Tag) 100ug
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