89-7817-99 ［取扱停止］Recombinant Mouse CD16-2/FCGR4 Protein (His&AVI Tag), Biotinylated(Active) 50ug PKSM040891
[Elabscience]
特徴
- 背景：Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses. Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc. Three groups are included for Fc γ receptors (FcR), and they are Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity for IgG. Genes encodes these receptors are diverse differing by species and cell types. The aggregation of FcR having immunoreceptor tyrosine-based activation motifs (ITAMs) activates sequentially src family tyrosine kinases and syk family tyrosine kinases that connect transduced signals to common activation pathways shared with other receptors. FcR with ITAMs elicit cell activation, endocytosis, and phagocytosis. Fcgr4 belongs to Fc γ RIII (CD16) group.
仕様
- サイズ：50ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_653142.2
- タグ種類：C-His-AVI, Biotinylated
- アミノ酸配列：Met 1-Gln 203
- 遺伝子構造：The amino acid sequence corronding to (Met 1-Gln 203) of mouse FCGR4 (NP_653142.2) was fused with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
- 活性：1. Measured by its ability to bind human IgG1 (Fc) in a functional ELISA.2. Labeling ratio of biotin to protein: 0.6
- 別名（遺伝子名）：4833442P21Rik Protein, Mouse;CD16-2 Protein, Mouse;FcgammaRIV Protein, Mouse;Fcgr3a Protein, Mouse;FcgRIV Protein, Mouse;Fcrl3 Protein, Mouse
- 分子量：24.2 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38904-Elabscience-PKSM040891.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7817-99
Recombinant Mouse CD16-2/FCGR4 Protein (His&AVI Tag), Biotinylated(Active) 50ug
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89-7817-98
Recombinant Mouse CD16-2/FCGR4 Protein (His&AVI Tag), Biotinylated(Active) 20ug
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