89-7817-46 ［取扱停止］Recombinant Mouse CD28/TP44 Protein (His & Fc Tag)(Active) 100ug PKSM040864
[Elabscience]
特徴
- 背景：CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 96 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_031668.3
- タグ種類：C-His-Fc
- アミノ酸配列：Met 1-Lys 149
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Lys 149) of mouse CD28 (NP_031668.3) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its binding ability in a functional ELISA.1. Immobilized mouse CD86 at 20 μg/ml (100 μl/well) can bind mouse CD28 Fc Chimera with a linear ranger of 6.4-800 ng/ml.2. Immobilized rat CD86 at 2 μg/ml (100 μl/well) can bind mouse CD28 Fc Chimera with a linear ranger of 6.4-160 ng/ml.
- 別名（遺伝子名）：T-cell-specific surface glycoprotein CD28;CD28;CH29-189K17.3
- 分子量：43 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38887-Elabscience-PKSM040864.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7817-46
Recombinant Mouse CD28/TP44 Protein (His & Fc Tag)(Active) 100ug
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89-7817-47
Recombinant Mouse CD28/TP44 Protein (His & Fc Tag)(Active) 200ug
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