89-7817-41 Recombinant Mouse Nogo Receptor/NgR Protein (His Tag)(Active) 100ug PKSM040861
[Elabscience]
特徴
- 背景：Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_075358.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 447
- 遺伝子構造：A DNA sequence encoding the mature form of mouse RTN4R (NP_075358.1) (Met 1-Ser 447) was expressed, fused with a polyhistidine tag at the C-terminus.
- 活性：1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant Mouse RTN4R at 2 μg/ml (100 μl/well) can bind biotinylated human RTN4 (GST Tag) with a linear range of 0.04-0.625 μg/ml.
- 別名（遺伝子名）：NgR;NgR1;NOGOR;Rtn4r
- 分子量：47 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38884-Elabscience-PKSM040861.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7817-40
Recombinant Mouse Nogo Receptor/NgR Protein (His Tag)(Active) 50ug
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89-7817-41
Recombinant Mouse Nogo Receptor/NgR Protein (His Tag)(Active) 100ug
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