89-7816-83 Recombinant Mouse GFRA2/GFRa2/GDNFRB Protein (His Tag) 100ug PKSM040829
[Elabscience]
特徴
- 背景：GFRA2 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA2 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA/GDNFRa acts as the ligand-binding component. Experiments have improved that GFRA2 genetic variants and age may play a role in Tardive dyskinesia (TD) susceptibility, but further work is required to confirm these findings.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_032141.2
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 441
- 遺伝子構造：A DNA sequence encoding the mouse GFRa2 (NP_032141.2) (Met 1-Ser 441) without the propeptide was expressed, fused with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：Gfra2, GFR alpha 2, GFR alpha-2
- 分子量：48.5 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38865-Elabscience-PKSM040829.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7816-83
Recombinant Mouse GFRA2/GFRa2/GDNFRB Protein (His Tag) 100ug
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89-7816-84
Recombinant Mouse GFRA2/GFRa2/GDNFRB Protein (His Tag) 200ug
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