89-7816-82 Recombinant Mouse RBP4 Protein (His Tag)(Active) 100ug PKSM040828
[Elabscience]
特徴
- 背景：Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_035385.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Leu 201
- 遺伝子構造：A DNA sequence encoding the mouse RBP4 (NP_035385.1) (Met 1-Leu 201) was fused with a polyhistidine tag at the C-terminus.
- 活性：Measured by its ability to bind alltrans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.The 50% binding concentration (BC50) is >0.5 ¦ÌM
- 別名（遺伝子名）：Rbp-4
- 分子量：22.8 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38864-Elabscience-PKSM040828.pdf
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89-7816-81
Recombinant Mouse RBP4 Protein (His Tag)(Active) 50ug
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89-7816-82
Recombinant Mouse RBP4 Protein (His Tag)(Active) 100ug
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