特徴
- 背景：Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of the S-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferation of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：E.coli
- 純度：> 90 % as determined by SDS-PAGE
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_058020.1
- タグ種類：N-His
- アミノ酸配列：Met1-Ile98
- 遺伝子構造：A DNA sequence encoding the mouse S100A11 (NP_058020.1) (Met1-Ile98) was expressed with a polyhistidine tag at the N-terminus.
- 別名（遺伝子名）：Protein S100-A11; Calgizzarin; Endothelial monocyte-activating polypeptide; EMAP; Protein S100-C; S100 calcium-binding protein A11; S100a11; S100c;cal;Emap1;EMAPI;S100A11;S100a14;S100c
- 分子量：13.2 kDa
- 組成：Lyophilized from sterile PBS, 10% glycerol, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38840-Elabscience-PKSM040794.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7816-16
Recombinant Mouse S100A11 Protein (His Tag) 100ug
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89-7816-15
Recombinant Mouse S100A11 Protein (His Tag) 20ug
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