89-7816-01 ［取扱停止］Recombinant Mouse Serpin F1/PEDF Protein (His Tag)(Active) 20ug PKSM040786
[Elabscience]
特徴
- 背景：Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_035470.3
- タグ種類：C-His
- アミノ酸配列：Met 1-Thr 417
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Thr 417) of mouse SerpinF1 (NP_035470.3) precursor was expressed with a C-terminal polyhistidine tag.
- 活性：Measured by its binding ability in a functional ELISA.Immobilized mouse SERPINF1-His at 10 μg/ml (100 μl/well) can bind biotinylated human GST-CSNK2A1 with a linear range of 0.31-2.5 μg/ml.
- 別名（遺伝子名）：AI195227 Protein, Mouse;EPC-1 Protein, Mouse;Pedf Protein, Mouse;Pedfl Protein, Mouse;Sdf3 Protein, Mouse
- 分子量：45.8 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38833-Elabscience-PKSM040786.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7816-01
Recombinant Mouse Serpin F1/PEDF Protein (His Tag)(Active) 20ug
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89-7816-02
Recombinant Mouse Serpin F1/PEDF Protein (His Tag)(Active) 50ug
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