89-7815-99 Recombinant Mouse Cystatin 7/CST7 Protein (Fc Tag)(Active) 20ug PKSM040785
[Elabscience]
特徴
- 背景：The cystatin superfamily members are important natural cysteine protease inhibitors present in a wide variety of organisms and are divided into three classes. Cystatin F, also known as leukocystatin and CMAP (Cystatin-like Metastasis-Associated Protein), is a type 2 cystatin and its expression is limited to hematopoietic cells, with the highest expression levels being observed in monocytes, dendritic cells, and certain types of T-cells. Furthermore, cystatin F mRNA becomes up-regulated during dendritic cell maturation, and thus suggests a specific role of cystatin F in immune regulation. Cystatin F is produced as a dimer, an inactive cathepsin inhibitor which is activated by chemical reduction. In addition, Cystatin F and its homologues have been observed expressing in various human cancer cell lines established from malignant tumors, and thus indicates a new diagnosis and prevention approach of certain human carcinomas metastasis.
仕様
- サイズ：20ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 93 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：O89098
- タグ種類：C-Fc
- アミノ酸配列：Met1-Gln144
- 遺伝子構造：A DNA sequence encoding the mouse CST7 (O89098) (Met1-Gln144) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- 活性：Measured by its ability to inhibit active Cathepsin L cleavage of a fluorogenic peptide substrate Z-LR-AMC, R&D Systems, Catalog # ES008.The IC50 is < 6 nM.
- 別名（遺伝子名）：Cystatin-F; Cystatin-like Metastasis-Associated Protein; Leukocystatin; CMAP; Cystatin-7; Cst7
- 分子量：41.4 kDa
- 組成：Lyophilized from sterile 25mM Tris, 0.15M NaCl, pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38832-Elabscience-PKSM040785.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7815-99
Recombinant Mouse Cystatin 7/CST7 Protein (Fc Tag)(Active) 20ug
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89-7815-98
Recombinant Mouse Cystatin 7/CST7 Protein (Fc Tag)(Active) 10ug
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