89-7815-75 Recombinant Mouse DR6/TNFRSF21 Protein (His Tag)(Active) 100ug PKSM040772
[Elabscience]
特徴
- 背景：TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.
仕様
- サイズ：100ug
- 種由来：Mouse
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by SDS-PAGE
- エンドトキシン濃度：< 1.0 EU per μg of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_055267.1
- タグ種類：C-His
- アミノ酸配列：Met 1-His 349
- 遺伝子構造：A DNA sequence encoding the mouse TNFRSF21 (NP_055267.1) extracellular domain (Met 1-His 349) was fused with a polyhistidine tag at the C-terminus.
- 活性：Immobilized mouse TNFRSF21-His at 10 μg/ml (100 μl/well) can bind biotinylated human APP-Fc with a linear range of 0.31-5 μg/ml.
- 別名（遺伝子名）：AA959878 Protein, DR6 Protein, R74815 Protein, TR7 Protein
- 分子量：35 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-38824-Elabscience-PKSM040772.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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89-7815-74
Recombinant Mouse DR6/TNFRSF21 Protein (His Tag)(Active) 50ug
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89-7815-75
Recombinant Mouse DR6/TNFRSF21 Protein (His Tag)(Active) 100ug
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